Cotylenin a是什么
WebThe active components, which we call cotylenin A and B, have been isolated, and some of their physical properties determined. WE have found substances in the culture filtrate of a fungus, strain ... WebNov 18, 2014 · Arsenic trioxide (ATO) is an approved treatment for acute promyelocytic leukemia (APL). It has also shown potential for treatment of multiple myeloma and various solid tumors including breast cancer. The requirement of high, toxic concentrations for the induction of apoptosis in non-APL and solid tumor cells is a major limitation for its use in …
Cotylenin a是什么
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WebAlso, cotylenin A has a complex structure where two carbocyclic five-membered rings are fused with a formidable carbocyclic eight-membered ring with a uniquely-structured, glucose-based sugar ... WebMar 8, 2024 · Cotylenin A is a glycosylated diterpene, which was isolated from the metabolites of Cladosporium sp. 501-7W, as a plant growth regulator. 5 Biological …
WebJul 14, 2024 · Cotylenin A and fusicoccin A (Fig. 7.1) are structurally related diterpene glucosides, which were isolated from different sources of Cladosporium sp. 501-7 W [1,2,3] and Phomopsis amygdali [], respectively.Although both these compounds exhibit potent plant growth activity, biological studies revealed that only cotylenin A induces the … WebCotylenin A, a plant growth regulator, and rapamycin, an inhibitor of mammalian target of rapamycin (mTOR), are potent inducers of differentiation of myeloid leukemia …
WebJul 1, 2003 · Cotylenin A, a Differentiation-inducing Agent, and IFN-α Cooperatively Induce Apoptosis and Have an Antitumor Effect on Human Non-Small Cell Lung Carcinoma … WebJun 4, 2010 · Cotylenin A (CN-A), a novel fusicoccane-diterpene glycoside, accelerates the differentiation of several types of myeloid cell lines and is a candidate for a new type of anticancer therapeutic ...
WebJul 1, 2008 · Cotylenin A or IPA immediately induced the expression of S100P mRNA and protein, and the differentiation of HL-60 cells was suppressed by treatment with antisense oligonucleotides against S100P, which suggests that S100P plays an important role in cell differentiation [28]. Cotylenin A enhanced the LCA acetate-induced differentiation …
Previous biological studies have revealed that cotylenin A combined in treatment can program cell death for a wide range of human cancer cell lines and suppress tumor growth. In addition, cotylenin A was found to induce the differentiation of myeloid leukemia cells when combined with a specific pharmaceutical drug. grant user db_owner roleWebFind jobs, housing, goods and services, events, and connections to your local community in and around Atlanta, GA on Craigslist classifieds. chipotle online customer service numberWebCotylenin A significantly stimulated both functional and morphological differentiation of leukaemia cells in 9 out of 12 cases and was more potent than those of all‐trans retinoic acid and 1α,25‐dihydroxyvitamin D3 (VD3) at inducing the monocytic differentiation of … chipotle online phone number customer serviceWebcotylenin A (1) and derivatives of fusicoccin A (2), are known to induce apoptosis and act as “molecular glues” to stabilize the protein–protein interaction (PPI) between the 14-3-3 hub pro- chipotle online phone numberWebDec 20, 2001 · Cotylenin A did not affect the erythroid or megakaryocytic differentiation of leukaemia cells. 12‐O‐tetradecanoyl phorbol‐13‐acetate (TPA) is a potent inducer of monocytic differentiation, but also induces megakaryocytic differentiation (Tabillio et al, 1983; Alitalo et al, 1988). These results indicate that cotylenin A is a potent and ... grant user access to azure file shareWebCotylenin A C33H50O11 CID 5477444 - structure, chemical names, physical and chemical properties, classification, patents, literature, biological activities, … grant user rights to start and stop servicesWebNov 18, 2014 · In the present study, we found that cotylenin A, a plant growth regulator and a potent inducer of differentiation in myeloid leukemia cells, significantly potentiated both ATO-induced inhibition of cell growth in a liquid culture, and ATO-induced inhibition of anchorage-independent growth in a semi-solid culture in human breast cancer MCF-7 … chipotle online order form