WebSep 15, 2016 · In patients with renal impairment, monitor renal function and CPK levels more than once weekly. Discontinue daptomycin for injection in patients with unexplained signs and symptoms of myopathy with CPK levels >1,000 U/L (~5× ULN), and in patients without symptoms and CPK levels >2,000 U/L (≥10× ULN). WebDec 13, 2024 · We analysed the incidence of elevated CPK between daptomycin alone and concomitant daptomycin and statins among studies defining CPK elevation as levels ≥ the upper limit of normal (ULN) or ≥5× ULN. We also analysed the incidence of rhabdomyolysis between the groups.
Doseindependent Daptomycin Associated …
WebElevated blood creatine phosphokinase (7.0%) Edema (7.0%) Abdominal pain (6.0%) Hypertension (6.0%) Pruritus (6.0%) Headache (5.4%) Diarrhea (5.2%) Sweating (5.0%) Bacteremia (5.0%) Sepsis (5.0%)... WebJul 1, 2014 · Purpose: A case series in which a novel dosing strategy for managing mild, asymptomatic creatine kinase (CK) increases associated with daptomycin therapy is … northern hills elementary school onalaska wi
A Case of Increased Creatin Kinase Level Caused by …
WebApr 1, 2009 · Daptomycin is a cyclic lipopeptide derived from a natural product of Streptomyces roseosporus. Its bactericidal effects stem from its ability to rapidly depolarise the membrane potential of Gram-positive bacteria. ... Fifteen of the 534 patients (2.8%) receiving daptomycin developed elevated creatine kinase levels compared to ten of … WebDaptomycin is reported to cause an elevation in creatine kinase levels, although frank rhabdomyolysis is rare. An even more infrequent occurrence is the simultaneous … WebPatients: One hundred and sixty adults with creatinine clearance (Clcr ) of 50 ml/minute or less who received daptomycin for at least 72 hours for complicated Gram-positive infections from 2008-2011. Measurements and main methods: Clinical and microbiologic outcomes were assessed at the end of daptomycin therapy. how to rock paint