Exebacase cf-301
WebAug 5, 2024 · Exebacase . Exebacase is under investigation in clinical trial NCT03163446 (Safety, Efficacy and Pharmacokinetics of CF-301 vs. Placebo in Addition to Antibacterial … WebMay 14, 2024 · Lysin exebacase (CF-301) is an anti-staphylococcal lysin with potent bactericidal activity against S. aureus and additionally against coagulase-negative …
Exebacase cf-301
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WebSep 23, 2024 · Exebacase, a recombinantly produced lysin (cell wall hydrolase), and comparator antibiotics were tested by the broth microdilution method against strain sets … WebDec 1, 2024 · Exebacase (lysin CF-301) is a potent antistaphylococcal lysin, with distinguishing features that include a low propensity for resistance, synergy with conventional antibiotics, activity against antibiotic-resistant strains, an extended post-antibiotic effect and, importantly, potent activity against biofilm bacteria ( Schuch et al., …
WebSep 4, 2024 · The focus will be on exebacase (CF-301), the Company's novel therapeutic candidate for Staph aureus bacteremia, including endocarditis, along with an update on the progress of its other pipeline assets. A live webcast of the presentation will be available on the Investors & Media section of the Company’s website at www.contrafect.com. The ... WebMay 24, 2024 · CF-301 (exebacase) is a recombinantly produced bacteriophage-derived lysin (cell wall hydrolase) and is the first agent of this class to enter clinical development …
WebNov 13, 2024 · Exebacase is a recombinantly-produced, purified cell wall hydrolase enzyme that results in rapid bacteriolysis, potent biofilm eradication, synergy with antibiotics, low … WebMar 11, 2024 · About Exebacase (CF-301): Exebacase is a recombinantly-produced lysin (cell wall hydrolase enzyme) with potent bactericidal activity against Staph aureus, a major cause of bloodstream infections ...
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WebJan 22, 2024 · Exebacase (CF-301) which is a prophage endolysin has good lytic activity against S. aureus [9,60]. Recently, it has been observed that human serum albumin and serum lysozyme have a synergistic ... enlisted specialty training programWebExebacase (CF-301) is a lysin with potent activity against Staphylococcus aureus ("Staph aureus"). Exebacase has the potential to be the first-in-class of a new treatment for … enlisted stalingrad full accessWebApr 1, 2024 · One of the lead compounds for this type of application is CF-301 (Exebacase), a Streptococcus suis prophage endolysin with activity against S. aureus [reviewed in Refs. 7, 17]. ... Besides CF-301, also the staphylococcal phage endolysin SAL200 (N-Rephasin) is currently in clinical development for the treatment of BSI (NCT03089697, ... enlisted soldiers record briefWebExebacase (CF-301) is a lysin (a bacteriophage-encoded peptidoglycan hydrolase) with potent activity against S. aureus in in vitro studies. 164,165 Exebacase was evaluated in a phase-2 RCT in combination with conventional antibiotics vs conventional antibiotics alone for the treatment of S. aureus BSI with or without right-sided endocarditis ... dr fowler knoxville plastic surgeryWebMay 23, 2024 · CF-301 is a lysin and member of a new class of targeted protein-based antimicrobials that has demonstrated activity against S. aureus in laboratory (in vitro) and animal studies, alone and in addition to conventional antibiotics. ... Bressler A, Evans D, Moran GJ, Rupp ME, Wise R, Corey GR, Zervos M, Douglas PS, Cassino C. Exebacase … dr. fowler gastrologist in concord ncWebFeb 17, 2024 · Exebacase (CF-301), a novel, anti-staphylococcal lysin (cell-wall hydrolase) is the first agent of this class to enter late-stage clinical development (Phase 3, NCT04160468) for the treatment of ... enlisted static closeout dateWebNov 18, 2024 · On October 2, 2024, ContraFect Corp. (NASDAQ:CFRX) announced that following a successful ‘end-of-Phase 2’ meeting with the FDA the company is planning to … enlisted sponsorship