High-affinity choline transporter 1
WebIn cholinergic neurons, high-affinity choline uptake in presynaptic terminals is the rate-limiting step in acetylcholine synthesis. Using information provided by the Caenorhabditis … Web31 de out. de 2000 · Here we report the molecular cloning and functional characterization of the human high-affinity choline transporter (hCHT1). The hCHT1 exhibits significant …
High-affinity choline transporter 1
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WebThe high-affinity choline transporter CHT1 mediates choline uptake, the rate-limiting and regulatory step in acetylcholine synthesis at cholinergic presynaptic terminals.CHT1-medated choline uptake is specifically inhibited by hemicholinium-3, which is a type of choline analog that acts as a competitive inhibitor.Although the substrate choline and … WebThe transporter protein was cloned and identified by Okuda and co-workers in 2000, and shown to exhibit high-affinity, sodium-dependent choline uptake ( Km ~2 μM) which …
Web5 de mai. de 2024 · To examine the action of tetrahydropyrimidines on the nematode high-affinity choline transporter, we generated HEK293 cell lines stably expressing the high-affinity choline transporter from C. elegans (CHO-1), the ortholog of CHT1 (Okuda et al., 2000), and measured the high-affinity choline uptake activity in the presence of … Web29 de jul. de 2014 · Highaffinity choline transporter 1 is involved in choline transport from the extracellular space to the neuron (48). Innexin 2 is required for the regulation of neuronal networks (49)....
WebThe Na(+)-dependent uptake of choline by CHT1 is the rate-limiting step for synthesis of acetylcholine. CHT1 is the integral membrane protein with 13 transmembrane segments, … WebThe molecular entity for the high-affinity choline transporter was identified and is designated CHT1, which mediates Na+- and Cl−-dependent choline uptake with high …
WebAt high concentrations, choline is transported primarily by a low-affinity and Na + -independent system that is inhibited by hemicholinium-3 (HC3) 10 with a high Ki of …
Web1 de out. de 2002 · High-affinity choline transporter 1. Gene. ChT. Status. UniProtKB reviewed (Swiss-Prot) Organism. Drosophila melanogaster ... Function. function. Imports choline from the extracellular space to the neuron with high affinity. Rate-limiting step in acetylcholine synthesis. Sodium ion and chloride ion dependent (By similarity). By ... money tree pictures plantWeb8 de mar. de 2006 · The high-affinity choline transporter at the molecular level. Despite the fact that the high-affinity choline uptake system was described in the 1960s, the genes for the high-affinity choline transporter proteins (CHT1) of Caenorhabditis elegans and rat have only recently been cloned (Okuda et al. 2000). money tree planning softwareWebA choline uptake system with a high affinity for choline has long been assumed to be present in cholinergic neurons. Very recently, the molecular entity for the high-affinity … money tree plant and feng shuiWebThe high-affinity choline transporter (CHT) is the rate-limiting determinant of acetylcholine (ACh) synthesis, yet the transporter remains a largely undeveloped target for the detection and… Expand 15 PDF Deficits in acetylcholine homeostasis, receptors and behaviors in choline transporter heterozygous mice M. Bazalakova, J. Wright, +4 authors money tree plant animal crossingWeb10 de jul. de 2015 · Synthesis and release of the neurotransmitter acetylcholine (ACh) is closely linked to the activity of the high-affinity choline transporter protein (CHT), but the impact of insulin receptor signaling and neuronal insulin resistance on these aspects of cholinergic function are unknown. money tree plant at home depotWeb29 de jul. de 2014 · Highaffinity choline transporter 1 is involved in choline transport from the extracellular space to the neuron (48). Innexin 2 is required for the regulation of … money tree plant botanical nameWebComponents. integral component of membrane / neuronal cell body / plasma membrane. General Function. Choline:sodium symporter activity. Specific Function. Imports choline from the extracellular space to the neuron with high affinity. Choline uptake is the rate-limiting step in acetylcholine synthesis. Sodium ion- and chloride ion-dependent. money tree plant brown spots on leaves