Imp-1/crd-bp function
Witryna29 sie 2024 · Introduction. Insulin-like growth factor II mRNA-binding protein 1 (IGF2BP1/IMP1), also known as the c-Myc coding region determinant-binding protein (CRD-BP) and zipcode-binding protein 1 (ZBP1), is a multifunctional RNA-binding protein that binds to diverse cancer-associated mRNAs to promote mRNA stability, … WitrynaPlasmid pIS1 IMP-1 long UTR from Dr. David Bartel's lab contains the insert IGF-II mRNA-binding protein 1 UTR and is published in Cell. 2009 Aug 21. 138(4):673-84. ... (a.k.a. CRD-BP, CRDBP, IMP-1, IMP1, VICKZ1, ZBP1) ... Long means that all functional alternative polyadenylation signals have been deleted.
Imp-1/crd-bp function
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WitrynaMouse coding region determinant–binding (mCRD‐BP) and human IGF‐II mRNA–binding 1 (hIMP‐1) proteins are orthologous mRNA‐binding proteins that recognize c‐myc and IGF‐II mRNA, respectively, and regul... Witryna1 paź 2010 · Europe PMC is an archive of life sciences journal literature. Introduction. CRD-BP, the coding region determinant binding protein, also known as insulin-like growth factor 2 mRNA-binding protein 1 (IMP-1 or IGF2BP-1), is a multifunctional RNA binding protein involved in different processes such as mRNA turnover, translation control, …
WitrynaPlasmid pMSCV PIG IMP-1-long-mut from Dr. David Bartel's lab contains the insert IGF-II mRNA-binding protein 1 and is published in Cell. 2009 Aug 21. 138(4):673-84. ... (a.k.a. CRD-BP, CRDBP, IMP-1, IMP1, VICKZ1, ZBP1) ... Long means that all functional alternative polyadenylation signals have been deleted. WitrynaCRD-BP belongs to a family of RNA binding proteins that show close a relation to the chicken β-actin zipcode-binding protein ZBP1[1] and the human forms of the protein …
WitrynaHere, we confirm that human CRD-BP/IMP-1 binds to c-myc mRNA and that it is predominantly expressed in fetal tissues. Moreover, hCRD-BP/IMP-1 expression was detected in cell lines of neoplastic origin and in selected primary tumors. In a series of 33 malignant and 10 benign mesenchymal tumors, 73% and 40%, respectively, were … WitrynaPlasmid pIS1 IMP-1 long UTR from Dr. David Bartel's lab contains the insert IGF-II mRNA-binding protein 1 UTR and is published in Cell. 2009 Aug 21. 138(4):673-84. ...
Witryna25 maj 2007 · CRD-BP/IMP-1 expression in HCT116 colon cancer cells (a) and adult human colon (b–e).Immunohistochemistry was performed as described in the Material and methods section by either using a rabbit anti-CRD-BP/IMP1 antibody (a and e), or by using a goat anti CRD-BP/IMP-1 antibody (b–d).In normal mucosa (b, d, e) CRD …
Witryna19 lis 2004 · CRD-BP/IMP-1 is highly related to IMP-2 and IMP-3, which together comprise a family of proteins that bind to the 5′-untranslated region of IGF-II leader 3 mRNA. ... In summary, our results revealed a novel function for CRD-BP in cell proliferation involving an IGF-II-dependent mechanism that appears independent of … highest peak of cujie slopeWitrynaInsulin -like growth factor II mRNA-binding protein, CRD-BP, VICKZ1), IMP-2 (IMP2, VICKZ2, p62) and IMP-3 (KOC1, VICKZ3), contain a unique combination of RNA recognition motifs and four hnRNP K homology domains. IMP-1 is abundant in embryonal tissues and in 81% of colon cancers, 58.5% of breast highest peak of india including pokWitrynaPlasmid pMSCV PIG IMP-1-long-mut from Dr. David Bartel's lab contains the insert IGF-II mRNA-binding protein 1 and is published in Cell. 2009 Aug 21. 138(4):673-84. ... (a.k.a. CRD-BP, CRDBP, IMP-1, IMP1, … how great thou art po polskuWitrynaPlasmid pMSCV PIG IMP-1-short from Dr. David Bartel's lab contains the insert IGF-II mRNA-binding protein 1 and is published in Cell. 2009 Aug 21. 138(4):673-84. ... Function; Biosensors; Chemogenetics; … highest peak of bhutanThe mouse Coding Region Determinant-Binding Protein (CRD-BP) is an RNA-binding protein. CRD-BP belongs to a family of RNA binding proteins that show close a relation to the chicken β-actin zipcode-binding protein ZBP1 and the human forms of the protein IMP-1, IMP-2 and IMP-3. Because of their close … Zobacz więcej CRD-BP is a 577 amino acid protein that contains 4 KH domains, 2 RRMs and a RGG box (Figure 2). CRD-BP and human IMP-1 are not identical but shows a high degree of resemblance. They are very closely related … Zobacz więcej CRD-BP and its orthologs have been shown to have the ability to bind CD44, beta-actin, c-myc, IGF2, H19 and tau RNA transcripts. CRD-BP has been shown to play a crucial role in cancer growth and invasion of tissues. CD44 proteins belong to a family of … Zobacz więcej highest peak of india k2 or kanchenjungaWitryna31 lip 2009 · Similarly, the half-life of a GBG mutant lacking an miR-183-binding site was not affected by CRD-BP, as compared to GBG containing the wild-type 577–1182 nt fragment of βTrCP1 (Figure 3 E). Knockdown of CRD-BP reduced expression of βTrCP1, but failed to do so when the function of miR-183 was inhibited (Figure 4 A). highest peak of hindu kush rangeWitryna19 lis 2004 · Thus, we have identified a dominant function for CRD-BP in cell proliferation of human K562 cells, involving a possible IGF-II-dependent mechanism … how great thou art piano music free