Nettetidentified Linc-ASEN as an lncRNA that suppresses cellular senescence in both human and mouse cells. p53 and p21 are essential for Linc-ASEN depletion-induced cellular senescence To elucidate functional role of Linc-ASEN in cellular senes-cence, we performed transcriptome analysis of Linc-ASEN-silenced MCF7 cells by RNA-Seq … NettetThe present invention relates to a composition for inducing cell senescence, containing a long intergenic noncoding RNA-associated with senescence (Linc-ASEN) expression inhibitor
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Nettet2010-jun. 20133 år. Staffing and recruitment to private and public sector. Specialized in finance, office and administrative positions. Interviewing, job analysis and HR … NettetMechanistic study showed that Linc-ASEN could directly bind to UPF1 to suppress p21 transcription by recruiting Polycomb Repressive Complex 1 (PRC1) and PRC2 to p21, … taty abroad instagram
A novel long noncoding RNA Linc-ASEN represses cellular …
NettetG@ Bð% Áÿ ÿ ü€ H FFmpeg Service01w ... NettetRecently, Up-frameshift protein 1 (UPF1) is reported to be downregulated in various cancers and its low expression is closely correlated with poor prognosis. UPF1 is well known as a master regulator of nonsense-mediated mRNA decay (NMD), which serves as a highly conserved mRNA surveillance process protecting cells from aberrant toxic … NettetMoreover, the Linc-ASEN-UPF1 complex repressed p21 expression post-transcriptionally by lowering p21 mRNA stability in association with DCP1A. Accordingly, Linc-ASEN levels were found inversely correlated with p21 mRNA levels in tumor tissues from patient-derived xenograft mice, in various human cancer tissues, and in aged mice tissues. taty alencar