Webb17 sep. 2024 · Meantime, we found that phosphorylation modification showed no obvious changes during high-altitude adaptation. Furthermore, Figure 11G and H demonstrated that lactylation modification mainly expressed at the protein molecular weight of 25kD. Interestingly, we found that lactylation modification was increased along with high … Webb27 nov. 2024 · Lactylation is a newly found lactate-derived post-translational modification, which is firstly reported on histone protein lysine residues to regulate …
Global profiling of protein lysine lactylation and potential target ...
Webb2 jan. 2024 · As a newly discovered protein posttranslational modification, lactate-derived histone lactylation has been found to play important roles in gene regulation and have profound effects on diverse ... Webb9 apr. 2024 · PKM2, pyruvate kinase type M2, has been shown to play a key role in aerobic glycolysis and to regulate the malignant behaviors of cancer cells. Recently, PKM2 has been revealed to hold dual metabolic and nonmetabolic roles. Working as both a pyruvate kinase with catalytic activity and a protein kinase that phosphorylates its substrates, … jawa velorex
DeepKla: An attention mechanism‐based deep neural network for protein …
Webb7 juni 2024 · In addition to the lactylated peptides, SIRT2 also showed delactylation activity against purified histone proteins and nucleosomes from HeLa cells as detected by immunoblotting using specific... Webb26 apr. 2024 · L -Lactylation is a recently discovered post-translational modification occurring on histone lysine residues to regulate gene expression. However, the substrate scope of lactylation, especially that in non-histone proteins, remains unknown, largely due to the limitations of current methods for analyzing lactylated proteins. Webb15 mars 2024 · Lysine lactylation (Kla) is a new type of posttranslational modification (PTM) that exists in mammalian, plant, and fungi cells [1 – 3]. Biochemically, Kla … kusadasi turkey earthquake